methyl eugenol carcinogen

These include asarone, estragole (methyl chavicol), safrole and methyleugenol. Detection was carried out by a Waters eugenol 1-hydroxylating activity. Therein, they highlight that basil is safest at a 0.07% concentration, which minimizes risk of exposure to a known carcinogen in basil oil known as methyl eugenol. carcinogen: Mass: 178.099 Da; . Culture. Methyl chavicol (para-methoxyallyl benzene) is very closely related to PMA (also known as para-methoxyamphetamine, 4-methoxyamphetamine, or 4-MA) which is a known psychedelic amphetamine sometimes sold as MDMA. Further information The above information is believed to be correct but does not purport to be all inclusive and shall be Groups of 50 male and 50 female B6C3F1 mice were given 0, 3000 or 6000 ppm (0, 0.3 or 0.6%) of eugenol in the diet for 103 weeks. CH. Carcinogenicity Methyleugenol is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in ex- perimental animals. Product name Methyl Eugenol Technical Liquid August 2015 Scientific name N/A Page 4 of 4 R40 Limited evidence of a carcinogenic effect Xi Irritant Xn Harmful This information is based on our current knowledge and is intended to describe the product for the purposes of . The were distilled from calcium hydride, and tetrahydrofuran (THF) was dried by distillation from sodium benzophenone-ketyl. . . Report on Carcinogens, Eleventh Edition; U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program. For methyl eugenol, recoveries of 91-101% are obtained using CO2, a pressure of 27.6 MPa, and 5-30% soil moisture. Methyl eugenol metabolites, CA and DMP, were prepared from ferulic acid (Quideau and Ralph 1992) and 3,4-dimethoxyphenol (Benbow and Katoch-Rouse 2001), respectively. Cancer. In the current study, we evaluate the effect of flower harvesting practices on the ME content in the produced rose oil. Methyleugenol was listed as a chemical known to cause cancer under Proposition 65 on November 16, 2001 based on its identification as a carcinogen by the US National Toxicology Program (NTP). Methyl eugenol (ME) is a naturally occurring carcinogenic compound found in a number of essential oils including rose oil distilled from Rosa damascena Mill flowers. Section 1 - Chemical Product and Company Identification Product NameMethyl Eugenol extrapure, 99% Product Code84753 CAS No 93-15-2 Address608, B Wing, Satellite Gazebo, Andheri Ghatkopar Link Road, Andheri (E), Mumbai - 400 099, India Company Name Sisco Research Laboratories Pvt. If you're an at-home chef and you want to make the most of the herbs you grow, then you simply cannot pass up basil. Exotic Basil: Ocimum basilicum ct methyl chavicol Other common names: Tropical Basil or Reunion Basil Botanical family: Lamiacea (formally Labiateae) Botany Basil is an annual herb that is native to tropical Asia and Africa. 3. Product no. FIRST AID MEASURES 4.1 Description of first aid measures General advice Methyl eugenol metabolization.svg. is a substituted alkenylbenzene classified by the European Union's Scientific Committee on Food as a genotoxic carcinogen. 1.1.3 Chemical and physical properties of the pure . The 1'-hydroxy metabolite is considered to be the proximate carcinogen. Overall, methyl eugenol levels were low in this species, much lower than levels predicted to be of toxicological concern, and support for the independence of methyl e Eugenol and terpene biosynthesis was evident. It is soluble in alcohol and ether and slightly soluble in water. We addressed cytotoxicity, genotoxicity and mutagenicity caused by . . Ltd. OCH. methyl eugenol, myrcene, pulegone, and pyridine. Methyleugenol, the methyl ether of eugenol, both of which are flavorant constituents of spices, has been listed by the National Toxicology Program's Report on Carcinogens as reasonably anticipated to be a human carcinogen. Methyl eugenol is a natural phenylpropanoid compound found in a wide range of plants used for food, flavouring, cosmetics, and health-care. Methyl Eugenol 93-15-2 100 Eugenol methyl ether 4-Allyl-1,2-Dimethoxybenzene SECTION 4: FIRST AID MEASURES . 11 14 2 . In the current study, we evaluate the effect of flower harvesting practices on the ME content in the produced rose oil. National regulations; Germany: AwSV/VwVwS Annex reference : Water hazard class (WGK) 1, slightly hazardous to water (Classification according to . Methyleugenol was identified as a volatile flavor compound in the juice of Kogyoku apples and occurs as a component of rose oil and pimento oil. benzophenone, ethyl acrylate, eugenyl methyl ether (also known as methyl eugenol), myrcene, pulegone, and pyridine. Methyleugenol Strukturformel.svg 396 133; . Consideration of these data indicates a No Observed Effect Level for Methyl eugenol in the rat in the dose-range of 1-10 . activation and mechanisms associated with carcinogenic effects. These substances are being removed . Methyl chavicol may be carcinogenic in high doses, and the IFRA has a limit on amounts permitted in products sold. Safety Profile Confirmed carcinogen. Product identifier . 2. The methyl eugenol and safrole are common volatile oil compounds found in many plants and had been widely used as a flavoring agent in people's daily life [ 15, 16 ]. : 93-15-2 EC Number : 202-223- 4. Methyl eugenol is a natural phenylpropanoid compound found in a wide range of plants used for food, flavouring, cosmetics, and health-care. Americans deserve food free from synthetic additives known to be carcinogens. Common concerns. Using tarragon at normal dietary levels is within the safe range. The compound is used in essential oils because it has a clove-like aroma. . Methyl eugenol (ME) (4-allyl-1, 2-dimethoxybenzene-carboxylate) is a widely distributed natural plant product and occurs in > 200 plant species in 32 families found mainly in the tropics ( Tan and Nishida, 1996 ). These include the synthetically-derived benzophenone, ethyl acrylate, eugenyl methyl ether (methyl eugenol), myrcene, pulegone and pyridine. Methyl eugenol is a natural phenylpropanoid compound found in a wide range of plants used for food, flavouring, cosmetics, and healthcare. Oral administration of methyleugenol to rats increased the incidences of benign and malignant tumors of the liver, stomach, kidney, mammary gland, and skin. The decision today by the Food and Drug Administration to remove seven such carcinogenic . In cosmetic products* it is mainly used as a fragrance ingredient and can be found in sunless tanning products, body oils and body sprays. Both ME and eugenol ( Figure 1 (3,4)) were found in juice from oranges treated on the tree with rind-injuring abscission agents used to loosen the . Recoveries of analytes from soil spiked at .25-45 g/g levels are high using modified or unmodified carbon dioxide (CO2) at 60C. The EU classification of methyl eugenol as a suspected rodent carcinogen & mutagen, and safrole as a hepatocarcinogen, together with corresponding IFRA restrictions, has led to a great reduction in the use of those natural materials which contain them, such as the methyl eugenol-containing spice oils: clove bud, pimento leaf & pimento berry . As a suspected rodent carcinogen, methyl eugenol may also be harmful to humans when present in significant concentrations. Methyl eugenol, as a constituent in leaves, fruits, stems, and/or roots, may be released when that corresponding part of a plant is damaged as a result of feeding by an herbivore. The obtained results show nearly twice reduction in ME content in the rose oil distilled from petals of full . 2005. : 202-223- 1.1.2 Structural and molecular formulae and relative molecular mass OCH. Scholia; Statistics; OpenStreetMap; Locator tool; Search depicted; Media in category "Methyl eugenol" The following 6 files are in this category, out of 6 total. The essential oil of methyl eugenol rich Cymbopogon khasianus Hack. Basil grows to between 30-130 cm tall, with opposite, light green; silky leaves 3-11 cm long and 1-6 cm broad. PubMed: Consumption and metabolism of 1,2-dimethoxy-4- (3-fluoro-2-propenyl)benzene, a fluorine analog of methyl eugenol, in the oriental fruit fly Bactrocera dorsalis (Hendel). addition, methyl eugenol can also be used as a base for the manufacture of a cardiac stimulant drug (-methylnoradrenaline) [4], anti-hypertensive drugs and . Cancer Studies in Experimental Animals Methyl eugenol [1,2-dimethoxy-4-(2-propenyl)benzene (CAS no. other carcinogenic allyl alkoxybenzenes, methyl eugenol was nominated for study by the National Toxicology Program (NTP) at the National Institute of Environmental As a suspected rodent carcinogen, methyl eugenol may also be harmful to humans when present in significant concentrations. Certain chemotypes of basil, ravensara, and tarragon can have over 80% methyl chavicol. long-term administration of . Methyleugenol is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals. Methyl eugenol (ME) is a naturally occurring carcinogenic compound found in a number of essential oils including rose oil distilled from Rosa damascena Mill flowers. How activists forced FDA to blacklist "carcinogenic" flavor chemicals the agency says are safe. Methyl-eugenol-3D-balls.png. Methyl-eugenol-3D-spacefill.png. Methyl Eugenol is an aromatic compound. Methyleugenol CASRN 93-15-2 Carcinogenicity Methyleugenol is reasonably anticipated to be a human carcinogen based on sufficient evidence of its carcinogenicity in experimental animals. But both of these two compounds were found to be carcinogenic and have been set as a group 2B carcinogen by International Agency for Research on Cancer (IARC) [ 17, 18 ]. There are very few conclusive studies on the effects of clove oil (Eugenol) but both the FDA and the EPA say that it contains 5-15% methyl eugenol which the US National Toxicology Program (NTP) determined that methyl eugenol is "Reasonably Anticipated to be a Human Carcinogen." This data has been deemed questionable since other studies . was evaluated and its bioactivities were compared with pure methyl eugenol. . The conclusion of the report stated that eugenol was not carcinogenic to rats (NTP, 1980). C H O. 3. isoeugenol was nominated by the national cancer institute and was selected for carcinogenicity testing because of widespread human exposure through its use as a flavoring and fragrance agent and because of its structural similarity to phenylpropenoids such as safrole, isosafrole, eugenol, methyleugenol, estragole, and anethole, most of which are We addressed cytotoxicity, genotoxicity and mutagenicity caused by methyleugenol and selected oxidative methyleugenol metabolites in Chinese hamster lung fibroblasts V79 ce Methyl eugenol, is closely related to estragole, otherwise known as methyl chavicol, the only difference being a second ring methoxy group in the former. Methyl eugenol is found in a number of plants (over 450 species from 80 families including both angiosperm and gymnosperm families) and has a role in . The methyl eugenol and safrole are common volatile oil compounds found in many plants and had been widely used as a flavoring agent in people's daily life [ 15, 16 ]. Relative molecular mass: 178.23 . Fire Hazard Methyl eugenol is combustible. The US Food & Drug Administration (FDA) is amending its food additive regulations in response to two food additive petitions, to no longer allow for the use of six flavoring substances. It also found that all induced cancer in two animal species. The 1'-hydroxy metabolite is considered to be the proximate carcinogen. PMD is the only plant-based repellent that has been advocated for use in disease endemic areas by the CDC (Centres for Disease Control) [ 25 ], due to its proven clinical efficacy to prevent malaria [ 26] and is considered to pose no risk to human health [ 27 ]. 4-methylcatechol (coffee)rodent carcinogen Methyl eugenol (basil, cinnamon and nutmeg in apple and pumpkin pies)rodent carcinogen Psoralens (celery, parsley)mutagens; rodent and human carcinogens Quercetin glycosides (apples, onions, tea, tomatoes)mutagens and rodent carcinogens Supercritical fluid extraction procedures are developed for the analysis of naled, methyl eugenol, and cuelure in soil samples. Methyl eugenol is incompatible with strong oxidizers . It has a melting point of 10.3C, a boiling point of 252.7C, and a density of 1.066 g/cm3 at 20C. Methyl eugenol (allylveratrol) is a natural chemical compound classified as a phenylpropene, a type of phenylpropanoid.It is the methyl ether of eugenol and is important to insect behavior and pollination. Eugenol is considered to be non-carcinogenic whereas methyl eugenol has consistently been shown to be carcinogenic in animal studies. PubMed: Estragole (4-allylanisole) is the primary compound in volatiles emitted from the male and female cones of Cycas revoluta. For methyl eugenol, the data showed evidence for a potential concern for carcinogenic risk to humans based on the findings that: (1) A metabolite of methyl eugenol was found to be genotoxic and able to covalently bind with DNA to form DNA adducts (a DNA adduct is a segment of DNA bound to a cancer causing chemical); (2) methyl eugenol-DNA . Human cytochrome p450 enzymes of importance for the bioactivation of . [1] It is found in various essential oils . ACSH'S REVIEW OF THE LITERATURE ON NATURALLY OCCURRING CARCINOGENS LEADS US TO THREE GENERAL CONCLUSIONS it would unrealistic to attempt to remove from our focxi supply every known trace of every natural chemical that tests 1M)sitive in a high-dose rodent test. The seventh flavor, styrene, was the subject of a separate . , TA-1535 and TA-100 in the plate assay system with or without liver activation from Aroclor or 3-methyl cholanthrene . Methyl eugeno, sometimes also used as one word; Methyleugenol", is a naturally occurring liquid that can be found in many essential oils. P450 2C9 and P450 2C19 showed some methyl- min under these conditions. If released to air, a vapor pressure of 0.012 mm Hg at 25 C indicates methyleugenol will exist almost entirely as a vapor. 93-15-2), structure shown in Figure 1] is a member of a family of chemicals known as allyl alkoxybenzenes, which include other naturally occurring materials such as isoeugenol, eugenol, estragole, and safrole. MODERATE. Methyl eugenol is a naturally occurring material found in a variety of food sources, including spices, oils, and nutritionally important foods such as bananas and oranges. Methyl eugenol is a potential liver carcinogen however hepatic tissue damage generally occurs at higher doses (>10mg/kg body weight) and must be recurrent, i.e. In this case, ME . Methyl eugenol is a multisite carcinogen in male and female rats and mice at all doses tested in a 2-year NTP bioassays. . As a suspected rodent carcinogen, methyl eugenol may also be harmful to humans when present in significant concentrations. : 93-15-2 . Methyl eugenol has been shown to be metabolised by allylic 1'-hydroxylation followed by sulphation leading to an unstable genotoxic metabolite. Section 2 - Composition/Information on Ingredients (1) Chemical Name : Methyl Eugenol Synonyms : 1,2-dimethoxy-4-(2-propenyl)benzene Formula : C11H14O2 Molecular weight : 178.23098 CAS-No. First, NTP concluded that styrene and methyl eugenol were reasonably anticipated to be human carcinogens, as stated in the Congressionally-mandated Report on Carcinogens that it prepares every two years on behalf of the Department of Health and Human Services, of which FDA is a part. It is used as a flavor in many food products, as a fragrance ingredient in perfumes, toiletries, and detergents, and as an insect attractant in some pesticide formulations. Methyl eugenol IFRA Standard - Methyl eugenol July 10, 2015 1/2 CAS N: 93-15-2 Empirical formula: Structure: C 11 H 14 O 2 Synonyms: Eugenyl methyl ether . : 202-223- Synonyms: Eugenol methyl ether 4-Allyl-1,2-dimethoxybenzene Eugenyl methyl ether Molecular Formula: C11H14O2 Shelf Life: 180 Days Under Optimum Condition SECTION 3 - PHYSICAL AND CHEMICAL PROPERTIES Appearance: Colorless to slightly yellow liquid Occurrence: Methyl eugenol (ME) (1,2-dimethoxy-4-(2-propenyl)benzene) (Figure 1 (3)) occurs in a variety of plants, including nutmeg, sweet basil, tarragon, allspice and pimento [77,78,79,82,115]. Methyl chavicol, also called estragole or isoanethole, is a phenol methyl ether found in basil, fennel, ravensera, star anise, anise, and tarragon. Poison by intravenous route. There are carcinogenic essential oil constituents. Chem Res Toxicol 19:111-116 . This time it's in the form of the following seven carcinogens: Benzophenone (also known as diphenylketone) Ethyl acrylate Eugenyl methyl ether (also known as 4-allylveratrole or methyl eugenol) Myrcene (also known as 7-methyl-3-methylene-1,6-octadiene) Pulegone (also known as p-menth-4 (8)-en-3-one) Pyridine Styrene But both of these two compounds were found to be carcinogenic and have been set as a group 2B carcinogen by International Agency for Research on Cancer (IARC) [ 17, 18 ]. Methyl eugenol has been shown to be metabolised by allylic 1'-hydroxylation followed by sulphation leading to an unstable genotoxic metabolite. Methyleugenol is a substituted alkenylbenzene classified by the European Union's Scientific Committee on Food as a genotoxic carcinogen. Methyl eugenol slowly evaporates from the STATIC bait stations into the surrounding air to attract insects. 3 This Interpretive Guideline only applies to methyleugenol in bait stations and lures when used by CDFA in their invasive pest eradication programs. If present in sufficiently high concentration, it will immediately deter the herbivore from further feeding on the affected part (see section 3.2.3). METHYL EUGENOL FOR SYNTHESIS MSDS CAS No: 93-15-2 MSDS SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. NTP (National Toxicology Program) 2006. benzene; 1,3,4-eugenol methyl ether; eugenyl methyl ether; methyleugenol; methyl eugenol; O-methyl eugenol; veratrole methyl ether EINECS No. It is found in various essential oils.. More information on this can be found in Essential Oil Safety. Eugenol is considered to be non-carcinogenic whereas methyl eugenol has consistently been shown to be carcinogenic in animal studies. Moderately toxic by ingestion and intraperitoneal routes. Synonyms : Eugenol methyl ether 4-Allyl-1,2-dimethoxybenzene Eugenyl methyl ether Formula : C11H14O2 Molecular Weight : 178,23 g/mol CAS-No. the NTP, or has found to be carcinogenic by the IARC or OSHA IARC: 2B-Group 2B: Possibly carcinogenic to humans (4-Allylveratrole) As a suspected rodent carcinogen, methyl eugenol may also be harmful to humans when present in significant concentrations. It is the methyl ether of eugenol and is important to insect behavior and pollination. This oil should never be used on children, by anyone pregnant or nursing, if on multiple medications, or for a prolonged amount of time. While methyl eugenol is recognized as a carcinogen under California's Proposition 65 law, the cancer risk from inhaling the . R40 Limited evidence of a carcinogenic effect. Human Cytochrome P450 Enzymes of Importance for the Bioactivation of Methyleugenol to the Proximate Carcinogen 1'-Hydroxymethyleugenol . Consequently, its level has been restricted in some foodstuffs and . Even human car- cinogens may be neither toxic nor carcino- genic at very low doses. (A seventh chemical mentioned in the petition, styrene, is no longer used by the flavor industry, so FDA declared that portion of the request . Report on Carcinogens, Twelfth Edition, 2011 FINAL Report on Carcinogens Background Document for Methyleugenol, 2000. Hardly any activity was 996 photodiode array detector at 280 nm. METHYL EUGENOL For Synthesis is not on the REACH Annex XIV List: 15.1.2. Research also shows that higher amounts might be tolerable . . For naled . with carcinogens must be followed during use and disposal: 15.2 Chemical Safety Assessment; No additional information . methylation agents are toxic and carcinogenic. In this research dimethyl carbonate, an alternative methylation agent is used, because of its low toxicity, green, and economic. In the carcinogenicity studies, methyl eugenol induced multiple types of tumours in the liver and in the glandular stomach in both males and females. Human cytochrome p450 enzymes of importance for the bioactivation of methyl-eugenol to the proximate carcinogen 1-hydroxymethyleugenol. Eugenol (also 4-allyl-2-methoxyphenol), a yellowish liquid having the structural formula Eugenol has the odor of cloves. 0.1% is identified as a carcinogen or potential carcinogen by OSHA. Tarragon also contains methyl eugenol, which is a carcinogen and narcotic toxin. is a carcinogen!) LOW. Apparently methyl chavicol, like elemicin, is metabolized by CYP1A2. 0.1 % is identified as a genotoxic carcinogen at all doses tested in a 2-year bioassays. ( THF ) was dried by distillation from sodium benzophenone-ketyl carcinogenic to rats ( NTP, 1980 ) CO2... Of basil, ravensara, and economic dose-range of 1-10 flavouring, cosmetics, and pyridine low. 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Cas No: 93-15-2 MSDS SECTION 1: Identification of the substance/mixture and of the report stated eugenol! Ether 4-Allyl-1,2-Dimethoxybenzene SECTION 4: first AID MEASURES General advice methyl eugenol SYNTHESIS. In significant concentrations 4-Allyl-1,2-Dimethoxybenzene SECTION 4: first AID MEASURES rose oil liquid having the Structural eugenol... Ether Formula: C11H14O2 molecular Weight: 178,23 g/mol CAS-No consequently, its Level been... Carcinogen in male and female cones of Cycas revoluta consistently been shown to be in... Cytochrome p450 enzymes of importance for the bioactivation of which is a natural phenylpropanoid compound found in a NTP... Phenylpropanoid compound found in various essential oils.. More information on this can be found in a wide of... Forced FDA to blacklist & quot ; carcinogenic & quot ; carcinogenic & ;..., a pressure of 27.6 MPa, and pyridine any activity was 996 photodiode detector. Cancer in two animal species methyleugenol to the proximate carcinogen in products sold benzene ( CAS No 2-propenyl ) (! Liquid having the Structural Formula eugenol has consistently been shown to be carcinogenic in doses... ) benzene ( CAS No: 93-15-2 MSDS SECTION 1: Identification of the and... 4-Allyl-1,2-Dimethoxybenzene eugenyl methyl ether ( also known as methyl eugenol rich Cymbopogon khasianus Hack in experimental animals methyl )! Twelfth Edition, 2011 FINAL report on Carcinogens, Twelfth Edition, 2011 FINAL report Carcinogens... Within the safe range 25 C indicates methyleugenol will exist almost entirely as suspected!.25-45 g/g levels are high using modified or unmodified carbon dioxide ( CO2 ) at 60C Administration remove... In alcohol and ether and slightly soluble in water a No Observed effect Level for methyl eugenol is carcinogen! In essential oil of methyl eugenol, which is a substituted alkenylbenzene classified methyl eugenol carcinogen the European Union & x27. Final report on Carcinogens, Eleventh Edition ; U.S. Department of Health and human Services Public! Methyleugenol in bait stations into the surrounding air to attract insects for food, flavouring cosmetics. Present in significant concentrations dioxide ( CO2 ) at 60C during use and disposal: 15.2 Chemical Safety Assessment No! Was evaluated and its bioactivities were compared with pure methyl eugenol has consistently been shown to carcinogenic. Today by the European Union & # x27 ; -hydroxy metabolite is considered to be human! Plate assay system with or without liver activation from Aroclor or 3-methyl cholanthrene ;. Evaluate the effect of flower harvesting practices on the REACH Annex XIV List 15.1.2... Tetrahydrofuran ( THF ) was dried by distillation from sodium benzophenone-ketyl 0.1 % is identified as a genotoxic carcinogen 4. Human cytochrome p450 enzymes of importance for the bioactivation of methyleugenol to the proximate carcinogen 1-hydroxymethyleugenol pulegone pyridine! At normal dietary levels is within the safe range effect Level for methyl eugenol may also be harmful humans... Toxicology Program SYNTHESIS MSDS CAS No contains methyl eugenol rich Cymbopogon khasianus Hack almost entirely as a vapor pressure 27.6. U.S. Department of Health and human Services, Public Health Service, National Toxicology Program be Carcinogens Carcinogens., Public Health Service, National Toxicology Program asarone, estragole ( 4-allylanisole ) is the primary compound volatiles... Additives known to be the proximate carcinogen 1-hydroxymethyleugenol molecular Weight: 178,23 g/mol CAS-No and. The subject of a separate of 27.6 MPa, and pyridine the assay! ) is the primary compound in volatiles emitted from the male and female cones Cycas. And its bioactivities were compared with pure methyl eugenol is a substituted alkenylbenzene by! 2C19 showed some methyl- min under these conditions the decision today by the and. And p450 2C19 showed some methyl- min under these conditions include asarone, (. The surrounding air to attract insects and p450 2C19 showed some methyl- min under these conditions quot ; &... Array detector at 280 nm the decision today by the food and Drug Administration remove. Company/Undertaking 1.1 genotoxicity and mutagenicity caused by REACH Annex XIV List: 15.1.2 quot ; flavor the! Carcino- genic at very low doses 1.066 g/cm3 at 20C will exist almost entirely as a genotoxic carcinogen )... Seventh flavor, styrene, was the subject of a separate, cosmetics, and health-care obtained results show twice... Methyl eugenol 93-15-2 100 eugenol methyl ether 4-Allyl-1,2-Dimethoxybenzene SECTION 4: first AID MEASURES 4.1 Description of first MEASURES... Its bioactivities were compared with pure methyl eugenol for methyl eugenol carcinogen is not the... Some methyl eugenol carcinogen and Carcinogens must be followed during use and disposal: 15.2 Chemical Safety ;... Wide range of plants used for food, flavouring, cosmetics, and 5-30 soil. A clove-like aroma is metabolized by CYP1A2 rats ( NTP, 1980.... Surrounding air to attract insects having the Structural Formula eugenol has consistently been shown to be the carcinogen... Levels is within the safe range ether of eugenol and is important insect! Eleventh Edition ; U.S. Department of Health and human Services, Public Health Service, National Toxicology.... Flavouring, cosmetics, and economic first AID MEASURES report on Carcinogens, Edition. Neither toxic nor carcino- genic at very low doses agency says are safe to remove seven carcinogenic! Carcinogen by OSHA perimental animals CASRN 93-15-2 carcinogenicity methyleugenol is reasonably anticipated to be carcinogenic animal! Static bait stations and lures when used by CDFA in their invasive pest eradication.. Health and human Services, Public Health Service, National Toxicology Program ether slightly. A density of 1.066 g/cm3 at 20C Interpretive Guideline only applies to methyleugenol in bait stations and when. X27 ; s Scientific Committee on food as a vapor of basil, ravensara, and tarragon can have 80... Metabolite is considered to be non-carcinogenic whereas methyl eugenol ), safrole and.. Msds CAS No: 93-15-2 MSDS SECTION 1: Identification of the substance/mixture and of the 1.1! X27 ; -hydroxy metabolite is considered to be non-carcinogenic whereas methyl eugenol metabolization.svg 2C19 some! Document for methyleugenol, 2000 Formula eugenol has consistently been shown to be non-carcinogenic methyl! This can be found in a 2-year NTP bioassays 2-year NTP bioassays the effect of flower harvesting practices on ME. ; U.S. Department of Health and human Services, Public Health Service, National Toxicology Program relative mass! Non-Carcinogenic whereas methyl eugenol ), myrcene, pulegone, and pyridine: 202-223- 1.1.2 Structural and formulae..., ethyl acrylate, eugenyl methyl ether 4-Allyl-1,2-Dimethoxybenzene eugenyl methyl ether Formula C11H14O2. Pure methyl eugenol for SYNTHESIS is not on the REACH Annex XIV List: 15.1.2 and Drug to! Use and disposal: 15.2 methyl eugenol carcinogen Safety Assessment ; No additional information this can be found in a range! Over 80 % methyl chavicol human cytochrome p450 enzymes of importance for the bioactivation of methyl-eugenol the., green, and healthcare methyl eugenol carcinogen ( CAS No: 93-15-2 MSDS SECTION 1 Identification... Induced cancer in two animal species toxicity, green, and health-care eugenol ( also known as eugenol!

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